NickelMaghrebV1, Main, Exploration, bibRecord, 000579

Protective effect of cactus (Opuntia flcus indica) cladode extract upon nickel-induced toxicity in rats

Identifieur interne : 000579 ( Main/Exploration ); précédent : 000578; suivant : 000580

Protective effect of cactus (Opuntia flcus indica) cladode extract upon nickel-induced toxicity in rats

Auteurs : Najla Hfaiedh [Tunisie] ; MOHAMED SALAH ALLAGUI [Tunisie] ; Mbarka Hfaiedh [Tunisie] ; ABDELFATTAH EL FEKI [Tunisie] ; Lazhar Zourgui [Tunisie] ; Francoise Croute [France]

Source :

Food and chemical toxicology [ 0278-6915 ] ; 2008.

RBID : Pascal:09-0077701

Descripteurs français

Pascal (Inist)
- Facteur de protection, Extrait, Nickel, Toxicité, Animal, Rat, Ficus, Antioxydant, Enzyme, Cholestérol, Triglycéride.
Wicri :
- topic : Nickel, Enzyme.

English descriptors

KwdEn :
- Alanine Transaminase (blood), Animal, Animals, Antioxidant, Antioxidants (metabolism), Aspartate Aminotransferases (blood), Blood Glucose (metabolism), Catalase (metabolism), Chemical and Drug Induced Liver Injury (enzymology), Chemical and Drug Induced Liver Injury (pathology), Chemical and Drug Induced Liver Injury (prevention & control), Cholesterol, Cholesterol (blood), Enzyme, Extract, Ficus, Glutathione Peroxidase (metabolism), L-Lactate Dehydrogenase (metabolism), Lipid Peroxidation (drug effects), Liver (chemistry), Male, Nickel, Nickel (antagonists & inhibitors), Nickel (toxicity), Opuntia (chemistry), Plant Extracts (pharmacology), Protective factor, Rat, Rats, Rats, Wistar, Superoxide Dismutase (metabolism), Thiobarbituric Acid Reactive Substances (metabolism), Toxicity, Triglyceride, Triglycerides (blood).
MESH :
- chemical , antagonists & inhibitors : Nickel.
- chemical , blood : Alanine Transaminase, Aspartate Aminotransferases, Cholesterol, Triglycerides.
- chemical , metabolism : Antioxidants, Blood Glucose, Catalase, Glutathione Peroxidase, L-Lactate Dehydrogenase, Superoxide Dismutase, Thiobarbituric Acid Reactive Substances.
- chemistry : Liver, Opuntia.
- drug effects : Lipid Peroxidation.
- enzymology : Chemical and Drug Induced Liver Injury.
- pathology : Chemical and Drug Induced Liver Injury.
- chemical , pharmacology : Plant Extracts.
- prevention & control : Chemical and Drug Induced Liver Injury.
- chemical , toxicity : Nickel.
- Animals, Male, Rats, Rats, Wistar.

Abstract

The purpose of this study carried out on male Wistar rats, was to evaluate the protective effects of regular ingestion of juice from the prickly pear cactus (Opuntia ficus indica) cladodes against nickel chloride toxicity. Rats were given either normal tap water or water containing 25% of cactus juice for one month. Then, rats of each group were injected daily, for 10 days, with either NiCl₂ solution (4 mg (30 μmol)/kg body weight) or with the same volume of saline solution (300 mM NaCl). Significant increases of lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase activities and of cholesterol, triglycerides and glucose levels were observed in blood of nickel-treated rats. In the liver, nickel chloride was found to induce an oxidative stress evidenced by an increase in lipid peroxidation and changes in antioxidant enzymes activities. Superoxide-dismutase (SOD) activity was found to be increased whereas glutathione peroxidase and catalase activities were decreased. These changes did not occur in animals previously given cactus juice, demonstrating a protective effect of this vegetal extract.

Affiliations:

Le document en format XML

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<term>Antioxidant</term>
<term>Antioxidants (metabolism)</term>
<term>Aspartate Aminotransferases (blood)</term>
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<term>Rats</term>
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<term>L-Lactate Dehydrogenase</term>
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<front><div type="abstract" xml:lang="en">The purpose of this study carried out on male Wistar rats, was to evaluate the protective effects of regular ingestion of juice from the prickly pear cactus (Opuntia ficus indica) cladodes against nickel chloride toxicity. Rats were given either normal tap water or water containing 25% of cactus juice for one month. Then, rats of each group were injected daily, for 10 days, with either NiCl<sub>2</sub>
 solution (4 mg (30 μmol)/kg body weight) or with the same volume of saline solution (300 mM NaCl). Significant increases of lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase activities and of cholesterol, triglycerides and glucose levels were observed in blood of nickel-treated rats. In the liver, nickel chloride was found to induce an oxidative stress evidenced by an increase in lipid peroxidation and changes in antioxidant enzymes activities. Superoxide-dismutase (SOD) activity was found to be increased whereas glutathione peroxidase and catalase activities were decreased. These changes did not occur in animals previously given cactus juice, demonstrating a protective effect of this vegetal extract.</div>
</front>
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Serveur d'exploration sur le nickel au Maghreb

Protective effect of cactus (Opuntia flcus indica) cladode extract upon nickel-induced toxicity in rats

Protective effect of cactus (Opuntia flcus indica) cladode extract upon nickel-induced toxicity in rats

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration sur le nickel au Maghreb
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